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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MARK2
All Species:
18.18
Human Site:
T639
Identified Species:
33.33
UniProt:
Q7KZI7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7KZI7
NP_001034558.2
788
87911
T639
G
S
I
F
S
K
F
T
S
K
F
V
R
R
N
Chimpanzee
Pan troglodytes
XP_001172839
796
89049
T649
F
A
H
A
R
R
G
T
S
T
G
I
I
S
K
Rhesus Macaque
Macaca mulatta
XP_001115591
788
87964
T639
G
S
I
F
S
K
F
T
S
K
F
V
R
R
N
Dog
Lupus familis
XP_540890
798
88683
T658
G
S
I
F
S
K
F
T
S
K
F
V
R
R
N
Cat
Felis silvestris
Mouse
Mus musculus
Q05512
776
86287
T636
G
S
I
F
S
K
F
T
S
K
F
V
R
R
N
Rat
Rattus norvegicus
O08679
722
80853
K584
I
F
S
K
F
T
S
K
F
V
R
R
N
L
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511751
793
88836
T646
F
S
H
A
R
R
G
T
S
T
G
I
I
S
K
Chicken
Gallus gallus
Q9IA88
798
88848
S643
C
I
Y
S
S
S
G
S
S
R
E
G
R
N
L
Frog
Xenopus laevis
NP_001080425
785
87931
V641
S
K
F
T
S
K
F
V
R
R
N
L
S
F
R
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
G799
Q
V
Q
E
V
E
L
G
G
G
A
Q
R
Q
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
N977
S
S
S
A
F
P
R
N
T
R
N
R
Q
T
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
P373
S
P
V
G
H
W
I
P
A
H
V
D
H
Y
G
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
P495
P
A
A
S
K
I
S
P
L
V
T
K
K
S
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
68.2
99.7
95.1
N.A.
96.6
89.9
N.A.
68.4
30.3
84.3
27.5
N.A.
N.A.
N.A.
38.8
N.A.
Protein Similarity:
100
80.4
99.7
96.2
N.A.
97.7
90.9
N.A.
80.5
48.7
91.7
42.7
N.A.
N.A.
N.A.
49.9
N.A.
P-Site Identity:
100
13.3
100
100
N.A.
100
6.6
N.A.
20
20
20
6.6
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
33.3
100
100
N.A.
100
6.6
N.A.
33.3
33.3
33.3
26.6
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
26.5
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.1
45.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
8
24
0
0
0
0
8
0
8
0
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% D
% Glu:
0
0
0
8
0
8
0
0
0
0
8
0
0
0
0
% E
% Phe:
16
8
8
31
16
0
39
0
8
0
31
0
0
8
8
% F
% Gly:
31
0
0
8
0
0
24
8
8
8
16
8
0
0
8
% G
% His:
0
0
16
0
8
0
0
0
0
8
0
0
8
0
0
% H
% Ile:
8
8
31
0
0
8
8
0
0
0
0
16
16
0
0
% I
% Lys:
0
8
0
8
8
39
0
8
0
31
0
8
8
0
24
% K
% Leu:
0
0
0
0
0
0
8
0
8
0
0
8
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
16
0
8
8
39
% N
% Pro:
8
8
0
0
0
8
0
16
0
0
0
0
0
0
0
% P
% Gln:
8
0
8
0
0
0
0
0
0
0
0
8
8
8
0
% Q
% Arg:
0
0
0
0
16
16
8
0
8
24
8
16
47
31
8
% R
% Ser:
24
47
16
16
47
8
16
8
54
0
0
0
8
24
8
% S
% Thr:
0
0
0
8
0
8
0
47
8
16
8
0
0
8
0
% T
% Val:
0
8
8
0
8
0
0
8
0
16
8
31
0
0
0
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _